Selected Publications

2017

Human Effector Memory T Helper Cells Engage with Mouse Macrophages and Cause Graft-versus-Host-Like Pathology in Skin of Humanized Mice Used in a Nonclinical Immunization Study. Am J Pathol.
Sundarasetty B, Volk V, Theobald SJ, Rittinghausen S, Schaudien D, Neuhaus V, Figueiredo C, Schneider A, Gerasch L, Mucci A, Moritz T, von Kaisenberg C, Spineli LM, Sewald K, Braun A, Weigt H, Ganser A, Stripecke R.
2017 Jun;187(6):1380-1398. doi: 10.1016/j.ajpath.2017.02.015. Epub 2017 Apr 20. PubMed PMID: 28432872.


2016

Leukemias and bones: humanizing the niche in mice. Blood.
Stripecke R.
2016 Dec 22;128(25):2874-2875. doi: 10.1182/blood-2016-11-746867. PubMed PMID: 28007730.


1(st) EMBL/DFG Women in Science Network Conference Heidelberg 2016: From Genes, Cells and the Immune System towards Therapies - Meeting Report. Eur J Immunol.
Stripecke R, Gouttefangeas C, Förster I.
2016 Nov;46(11):2492-2495. doi: 10.1002/eji.201670115. PubMed PMID: 27813068.


Dendritic-tumor cell hybrids induce tumor-specific immune responses more effectively than the simple mixture of dendritic and tumor cells. Cytotherapy.
Pinho MP, Sundarasetty BS, Bergami-Santos PC, Steponavicius-Cruz K, Ferreira AK, Stripecke R, Barbuto JA.
2016 Apr;18(4):570-80. doi: 10.1016/j.jcyt.2016.01.005. PubMed PMID: 26971685.


TLR8 regulation of LILRA3 in monocytes is abrogated in human immunodeficiency virus infection and correlates to CD4 counts and virus loads. Retrovirology.
Low HZ, Ahrenstorf G, Pommerenke C, Habermann N, Schughart K, Ordóñez D, Stripecke R, Wilk E, Witte T.
2016 Mar 12;13:15. doi: 10.1186/s12977-016-0248-y. PubMed PMID: 26969150; PubMed Central PMCID: PMC4788896.


The gender gap: discrepant human T-cell reconstitution after cord blood stem cell transplantation in humanized female and male mice. Bone Marrow Transplant.
Volk V, Schneider A, Spineli LM, Grosshennig A, Stripecke R.
2016 Apr;51(4):596-7. doi: 10.1038/bmt.2015.290. Epub 2015 Nov 23. PubMed PMID: 26595075; PubMed Central PMCID: PMC4827003.


2015

Generation of lentivirus-induced dendritic cells under GMP-compliant conditions for adaptive immune reconstitution against cytomegalovirus after stem cell transplantation. J Transl Med.
Sundarasetty BS, Kloess S, Oberschmidt O, Naundorf S, Kuehlcke K, Daenthanasanmak A, Gerasch L, Figueiredo C, Blasczyk R, Ruggiero E, Fronza R, Schmidt M, von Kalle C, Rothe M, Ganser A, Koehl U, Stripecke R.
2015 Jul 22;13:240. doi: 10.1186/s12967-015-0599-5. PubMed PMID: 26198406; PubMed Central PMCID: PMC4511080.


Generation of lentivirus-induced dendritic cells under GMP-compliant conditions for adaptive immune reconstitution against cytomegalovirus after stem cell transplantation. J Transl Med.
Sundarasetty BS, Kloess S, Oberschmidt O, Naundorf S, Kuehlcke K, Daenthanasanmak A, Gerasch L, Figueiredo C, Blasczyk R, Ruggiero E, Fronza R, Schmidt M, von Kalle C, Rothe M, Ganser A, Koehl U, Stripecke R.
2015 Jul 22;13:240. doi: 10.1186/s12967-015-0599-5. PubMed PMID: 26198406; PubMed Central PMCID: PMC4511080.


Lentivirus-induced 'Smart' dendritic cells: Pharmacodynamics and GMP-compliant production for immunotherapy against TRP2-positive melanoma. Gene Ther.
Sundarasetty BS, Chan L, Darling D, Giunti G, Farzaneh F, Schenck F, Naundorf S, Kuehlcke K, Ruggiero E, Schmidt M, von Kalle C, Rothe M, Hoon DS, Gerasch L, Figueiredo C, Koehl U, Blasczyk R, Gutzmer R, Stripecke R.
2015 Sep;22(9):707-20. doi: 10.1038/gt.2015.43. Epub 2015 May 28. PubMed PMID: 25965393; PubMed Central PMCID: PMC4561294


Engineered dendritic cells from cord blood and adult blood accelerate effector T cell immune reconstitution against HCMV. Mol Ther Methods Clin Dev.
Daenthanasanmak A, Salguero G, Sundarasetty BS, Waskow C, Cosgun KN, Guzman CA, Riese P, Gerasch L, Schneider A, Ingendoh A, Messerle M, Gabaev I, Woelk B, Ruggiero E, Schmidt M, von Kalle C, Figueiredo C, Eiz-Vesper B, von Kaisenberg C, Ganser A, Stripecke R.
2015 Jan 7;1:14060. doi: 10.1038/mtm.2014.60. eCollection 2015. PubMed PMID: 26052526; PubMed Central PMCID: PMC4449014.


2014

Lentivirus-Induced Dendritic Cells (iDC) for Immune-Regenerative Therapies in Cancer and Stem Cell Transplantation. Biomedicines.
Stripecke R
2014 Aug 21;2(3):229-246. doi: 10.3390/biomedicines2030229. Review. PubMed PMID: 28548069; PubMed Central PMCID: PMC5344221.


Evaluation of suitable target antigens and immunoassays for high-accuracy immune monitoring of cytomegalovirus and Epstein-Barr virus-specific T cells as targets of interest in immunotherapeutic approaches. J Immunol Methods.
Tischer S, Dieks D, Sukdolak C, Bunse C, Figueiredo C, Immenschuh S, Borchers S, Stripecke R, Maecker-Kolhoff B, Blasczyk R, Eiz-Vesper B.
2014 Jun;408:101-13. doi: 10.1016/j.jim.2014.05.011. Epub 2014 May 28. PubMed PMID: 24877879.


Dendritic cell-mediated immune humanization of mice: implications for allogeneic and xenogeneic stem cell transplantation. J Immunol.
Salguero G, Daenthanasanmak A, Münz C, Raykova A, Guzmán CA, Riese P, Figueiredo C, Länger F, Schneider A, Macke L, Sundarasetty BS, Witte T, Ganser A, Stripecke R.
2014 May 15;192(10):4636-47. doi: 10.4049/jimmunol.1302887. Epub 2014 Apr 16. PubMed PMID: 24740501


Semaphorin 3A alters endothelial cell immunogenicity by regulating Class II transactivator activity circuits. Transfusion.
Schlahsa L, Zhang H, Battermann A, Verboom M, Immenschuh S, Eiz-Vesper B, Stripecke R, Engelmann K, Blasczyk R, Figueiredo C.
2014 Aug;54(8):1961-70. doi: 10.1111/trf.12631. Epub 2014 Mar 28. PubMed PMID: 24673430.


2013

Monitoring dendritic cell and cytokine biomarkers during remission prior to relapse in patients with FLT3-ITD acute myeloid leukemia.
Rickmann M, Macke L, Sundarasetty BS, Stamer K, Figueiredo C, Blasczyk R, Heuser M, Krauter J, Ganser A, Stripecke R.
Ann Hematol. 2013 Apr 25. [Epub ahead of print]


The innovative evolution of cancer gene and cellular therapies.
Lam P, Khan G, Stripecke R., Hui KM, Kasahara N, Peng KW, Guinn BA.
Cancer Gene Ther. 2013 Mar;20(3):141-9. doi: 10.1038/cgt.2012.93. Epub 2013 Feb 1.


Lentivirus-induced dendritic cells for immunization against high-risk WT1(+) acute myeloid leukemia.
Sundarasetty BS, Singh VK, Salguero G, Geffers R, Rickmann M, Macke L, Borchers S, Figueiredo C, Schambach A, Gullberg U, Provasi E, Bonini C, Ganser A, Woelfel T, Stripecke R.
Hum Gene Ther. 2013 Feb;24(2):220-37. doi: 10.1089/hum.2012.128.


2012

Integrase-defective lentiviral vectors encoding cytokines induce differentiation of human dendritic cells and stimulate multivalent immune responses in vitro and in vivo.
Daenthanasanmak A, Salguero G, Borchers S, Figueiredo C, Jacobs R, Sundarasetty BS, Schneider A, Schambach A, Eiz-Vesper B, Blasczyk R, Weissinger EM, Ganser A, Stripecke R.
Vaccine. 2012 Jul 20;30(34):5118-31. doi: 10.1016/j.vaccine.2012.05.063. Epub 2012 Jun 9.


Identity, potency, in vivo viability, and scaling up production of lentiviral vector-induced dendritic cells for melanoma immunotherapy.
Pincha M, Sundarasetty BS, Salguero G, Gutzmer R, Garritsen H, Macke L, Schneider A, Lenz D, Figueiredo C, Blasczyk R, Ruggiero E, Schmidt M, von Kalle C, Puff C, Modlich U, von der Leyen H, Wicke DC, Ganser A, Stripecke R.
Hum Gene Ther Methods. 2012 Feb;23(1):38-55. doi: 10.1089/hgtb.2011.170.


2011

Preconditioning therapy with lentiviral vector-programmed dendritic cells accelerates the homeostatic expansion of antigen-reactive human T cells in NOD.Rag1-/-.IL-2rγc-/- mice.
Salguero G, Sundarasetty BS, Borchers S, Wedekind D, Eiz-Vesper B, Velaga S, Jirmo AC, Behrens G, Warnecke G, Knöfel AK, Blasczyk R, Mischak-Weissinger E, Ganser A, Stripecke R.
Hum Gene Ther. 2011 Oct;22(10):1209-24. doi: 10.1089/hum.2010.215. Epub 2011 Jul 27.


Elevated frequencies of leukemic myeloid and plasmacytoid dendritic cells in acute myeloid leukemia with the FLT3 internal tandem duplication.
Rickmann M, Krauter J, Stamer K, Heuser M, Salguero G, Mischak-Weissinger E, Ganser A, Stripecke R.
Ann Hematol. 2011 Sep;90(9):1047-58. doi: 10.1007/s00277-011-1231-2. Epub 2011 Apr 26.


Lentiviral vectors for induction of self-differentiation and conditional ablation of dendritic cells.
Pincha M, Salguero G, Wedekind D, Sundarasetty BS, Lin A, Kasahara N, Brugman MH, Jirmo AC, Modlich U, Gutzmer R, Büsche G, Ganser A, Stripecke R.
Gene Ther. 2011 Aug;18(8):750-64. doi: 10.1038/gt.2011.15. Epub 2011 Mar 17.


2010

Lentiviral vectors for immunization: an inflammatory field.
Pincha M, Sundarasetty BS, Stripecke R.
Expert Rev Vaccines. 2010 Mar;9(3):309-21. doi: 10.1586/erv.10.9. Review.


Monocytes transduced with lentiviral vectors expressing hepatitis C virus non-structural proteins and differentiated into dendritic cells stimulate multi-antigenic CD8(+) T cell responses.
Jirmo AC, Koya RC, Sundarasetty BS, Pincha M, Yu GY, Lai M, Bakshi R, Schlaphoff V, Grabowski J, Behrens G, Wedemeyer H, Stripecke R.
Vaccine. 2010 Jan 22;28(4):922-33. doi: 10.1016/j.vaccine.2009.10.150. Epub 2009 Nov 18.


2009

Lentiviral vector-mediated genetic programming of mouse and human dendritic cells.
Stripecke R.
Methods Mol Biol. 2009;506:139-58. doi: 10.1007/978-1-59745-409-4_11.


2007

Lentiviral vectors with CMV or MHCII promoters administered in vivo: immune reactivity versus persistence of expression.
Kimura T, Koya RC, Anselmi L, Sternini C, Wang HJ, Comin-Anduix B, Prins RM, Faure-Kumar E, Rozengurt N, Cui Y, Kasahara N, Stripecke R.
Mol Ther. 2007 Jul;15(7):1390-9. Epub 2007 May 1.


Lentiviral vector-mediated autonomous differentiation of mouse bone marrow cells into immunologically potent dendritic cell vaccines.
Koya RC, Kimura T, Ribas A, Rozengurt N, Lawson GW, Faure-Kumar E, Wang HJ, Herschman H, Kasahara N, Stripecke R.
Mol Ther. 2007 May;15(5):971-80. Epub 2007 Mar 20.